Home Health&Fitness Amondys 45 (casimersen) for Duchenne: Side Effects & Warnings

Amondys 45 (casimersen) for Duchenne: Side Effects & Warnings


Generic drug: casimersen

Brand name: Amondys 45

What is Amondys 45 (casimersen), and how does it work?

Amondys 45 (casimersen) is an antisense oligonucleotide indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping.

What are the side effects of Amondys 45?

Side effects of Amondys 45 include:

What is the dosage for Amondys 45?

Monitoring To Assess Safety

Serum cystatin C, urine dipstick, and
urine protein-to-
creatinine ratio (UPCR) should be measured before starting
Amondys 45. Consider measurement of glomerular filtration rate prior to
initiation of Amondys 45. Monitoring for kidney toxicity during treatment is
recommended. Obtain the urine sample prior to infusion of Amondys 45 or at least
48 hours after infusion.

Dosing Information

The recommended dosage of
Amondys 45 is 30 milligrams per kilogram administered once weekly as a 35 to 60-minute intravenous infusion via an in-line 0.2 micron filter.

If a dose of
Amondys 45 is missed, it may be administered as soon as possible after the scheduled dose.

What drugs interact with Amondys 45?

No Information Provided

Is Amondys 45 safe to use while pregnant or breastfeeding?

Medically Reviewed on 4/2/2021

References


All sections courtesy of the U.S. Food and Drug Administration



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